Patient Comments: Primary Sclerosing Cholangitis - Medications


What medications were helpful with the symptoms you experienced with primary sclerosing cholangitis? Submit Your Comment

Comment from: M66Maryann, 45-54 Female (Patient) Published: May 30

My itching was severe with primary sclerosing cholangitis. I felt desperate and could not function normally. Nor could I sleep normally. Prior to diagnosis, I had taken sertraline for several years to treat anxiety. I weaned myself from it, and promptly began itching. In hindsight, I believe the sertraline had prevented the itching. After diagnosis, I got back on it. It did nothing to relieve the itching. I tried hydroxyzine, ursodiol, rifampin, and cyproheptadine. None worked. Cholestyramine worked. It is a powder that you mix into a liquid and drink. I take 3 doses daily, along with sertraline, and cyproheptadine. It took about 2 weeks to handle the itching.

Comment from: Jason, 45-54 Male (Patient) Published: February 07

Ursofalk (ursodeoxycholic acid) greatly reduced the pain I experienced in my liver because of primary sclerosing cholangitis. If I stop taking it (forget to take or run out), the pain increases so it definitely makes a difference. It does not reduce the disease, but does reduce the pain. Questran Light (cholestyramine anhydrous) reduced extreme itchiness.

Comment from: sundance, 55-64 Male (Patient) Published: October 14

I was prescribed ursodiol upon diagnosis of primary sclerosing cholangitis in 2006 and have been using it ever since. Since taking it I have not experienced another septic episode. However, my most recent MRI did reveal a new stricture in my bile duct which confirms that ursodiol does not impede progression of the disease.


Liver disease refers to any abnormal process that affects the liver. See Answer

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