Patient Comments: Cortisone Injection - Side Effects


What side effects (if any) did you experience with your cortisone injection? Submit Your Comment

Comment from: Charlotte, 75 or over Female (Patient) Published: June 16

I had cortisone injections 4 days ago in my right knee and right hip. For the past two days I have been in incredible pain in my hip; it is sore and throbs constantly. I have had a partial hip replacement and the scar is now red and angry looking also. My headache has been excruciating for three days, and I have been dizzy and lethargic. Also, I am fluctuating between sweats and chills. I tried an ice pack on the hip, but not much help there. I'm not sure about having cortisone again.

Comment from: Alan, 55-64 Male (Patient) Published: June 04

I had a cortisone injection in my spine L1/S1 due to a trapped nerve, and in my hip due to bursitis and tendinitis. Within a few hours my pulse was racing, blood pressure elevated, I felt extremely nervous and fatigued and had insomnia on the first night. The pain had already subsided prior to the injections so these are whole new symptoms to deal with. Too early to say if it will guide my decision to have the injection again in the future if required.

Comment from: Terresa, 45-54 Female (Patient) Published: June 04

I got a cortisone injection in my knee yesterday and today I don't feel well. My face is superhot and I don't feel well. I am hoping I feel better soon. I also have a horrible headache.

Comment from: Suffering dude, 55-64 Male (Patient) Published: May 26

I had a cortisone injection for my trigger finger a few years ago under ultrasound, and had no problems. Recently I had another injection as the problem has reoccurred. The first few days I was in agony. Pain was unbearable. Then it got better and it’s back again. I will not go through this again. Exercise and vitamins seem to reduce pain. No more injections.

Comment from: Jim, 65-74 Male (Patient) Published: May 17

I had my second cortisone injection in my left shoulder two weeks ago. My shoulder feels good, but when I do anything physical I get bad sweats, loss of breath, and feel weak.

Comment from: Regret injection ??, 35-44 Female (Patient) Published: May 05

It is four days after cortisone injection and I still have pain. Immediately after injection I started pacing in the doctor's office due to pain. When I got home I sat down to eat dinner and couldn't get up. I couldn't walk, bend, or stretch my leg, and couldn't put any weight on it. I have a prosthesis so this completely disabled me. My blood pressure (BP) and heart rate were high. I ended up in the emergency room (ER) by ambulance, and now on hydrocodone and a walker! I don't recommend this injection. The pain is worse than ever.

Comment from: Dar1313, 45-54 Male (Patient) Published: May 04

I got the cortisone injections for osteoarthritis of both shoulders, along with swelling of hand and foot from lupus. Never had a shot before and will never again! Within 4 hours, my body starts aching, get fever, and blood pressure (BP) shoots through the roof. Not only that, but constant gut rot, gurgling and explosive defecation. Muscle cramps and anxiety, especially after dark. It’s been this way for over 2 weeks. When I contacted both my doctor and internist, they tell me it was a rare thing but should subside soon; not soon enough.

Comment from: Rhonda, 55-64 Female (Patient) Published: April 09

I got a cortisone shot in my shoulder for bursitis five days ago. For the first two days the pain disappeared. Even though some of the pain has returned it is still better. Today I keep having hot flashes along with not feeling well. I’m 59 and a diabetic. My glucose number has been spiked ever since the day I got the shot. I’ve read somewhere these are typical symptoms after a cortisone injection. It’s scary to feel this way.

Comment from: Claire W, 45-54 Female (Patient) Published: March 31

I had a cortisone injection in my knee yesterday evening. I woke up this morning wet through from night sweats. The worst I’ve ever had. Then for the next few hours I alternated between feeling hot and shivering. Now it has been 24 hours since having it. The skin on my face is hot to the touch. I have headache, especially behind my eyes, and my heart is racing. The good news is that I am already feeling some relief from pain, however I have not felt well enough to get up and about all day.

Comment from: safedriver, 75 or over Male (Patient) Published: March 29

I had a cortisone injection in my right hip 2 days ago. I was OK for about 3-4 hours, then I started to experience some pain in my right hip and thigh. The pain became so intense that I was sweating profusely and passed out twice. This extreme pain lasted about 20 hours before subsiding. I also have massive bruising on my upper thigh from the injection site down the front and around to the rear of my upper thigh. If I had known of the intense pain I would not have had the cortisone injection.


What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow
Comment from: one_blonde_mom , 55-64 Female (Patient) Published: March 15

I've had multiple cortisone injections with no problems at all. I had one in each knee 2 days ago and I have had a tremendous headache, nausea and diarrhea since then. Really surprising and disappointing.

Comment from: Beena, 55-64 Female (Patient) Published: March 12

It is 2 weeks since I had cortisone shot in my knee. I feel unwell, have a bad taste in my mouth, and white patches in the throat. My stomach is grumbling, I feel fatigued, and don’t feel good. No energy. I am being treated for yeast infection in my mouth. I just want to feel normal again. The shot is not worth this misery.

Comment from: Jbear77 , 35-44 Male (Patient) Published: February 16

I had a cortisone injection into my bicep tendon and front shoulder joint. No real problem to start with besides a little pain once the needle entered the sheath of the tendon. But roughly 12 hours later I had severe stomach cramps and diarrhea. It is still going on and it’s been more than 24 hours. I am also not feeling so well in the head, not a headache, but just unwell. Last cortisone injection I got I had zero symptoms.

Comment from: AfromFlorida, 45-54 Female (Patient) Published: January 25

I had my first cortisone injection in my right hip for severe arthritis. Within 4 hours I had a severe headache above my eyes, worse on the right. I couldn't sleep, I had night sweats and pounding heart. Twenty four hours later, I have severe headache, like the worst hangover ever. No changes in hip pain but it may be too soon. The doctor says I need a total hip replacement, on the first visit. Thinking of doing that to avoid headache repeatedly.

Comment from: Judi, 65-74 Female (Patient) Published: January 14

I had extreme pain, like electric shock, shooting to the top of my fingers. I had 2 cortisone injections one week ago into the base of my fingers, and now I am getting shooting pain and electric shock feeling in my hands and fingers. I have difficulty bending my fingers, and now the swelling at the base of my fingers is worse than it was.

Comment from: JE , 35-44 Female (Patient) Published: January 12

I had a cortisone injection in my hip 3 days ago for bursitis. I was extremely sore from the injection the entire first day. It was hard to walk. That night I was restless and had night sweats along with shivering. The next day the soreness lessened as the day went on but I got a bad headache, my face flushed, and my tongue started feeling numb. Today my bursitis pain is gone, but I haven’t been able to sleep and my tongue, roof of my mouth, and lips feel numb and I feel really dehydrated.

Comment from: Vivian, 55-64 Female (Patient) Published: January 11

I got a cortisone injection in my knee, and 5 hours later, I am sick to my stomach and have a weird taste in my mouth.

Comment from: Lee, 65-74 Female (Patient) Published: January 08

I had a cortisone injection in my sacroiliac (SI) joint. It did help my pain but the side effects were flushed cheeks, headache and a strange taste in my mouth when burping. This has happened every time I get the joint injection.

Comment from: Crys, 55-64 Female (Patient) Published: January 07

I had a cortisone injection in my hip 3 weeks ago and have completely lost my sense of taste.

Comment from: Fred, 75 or over Male (Patient) Published: November 02

I had a cortisone injection for arthritis in a knee. Immediately after the injection the pain was almost completely gone. Also, my back pain from an old surgery disappeared as did rosacea inflammation around my eyes. However, over the next 5 days all of the pain returned, my face was flushed and hot, my head ached above my eyes, and I was jittery and unable to sleep. Don’t think this was the answer for me.

Comment from: MBW, 65-74 Female (Patient) Published: October 26

I've had two cortisone injections in my right hip for osteoarthritis, one last July and one two days ago (late October). Both were followed within two days with diarrhea, extreme fatigue, inability to concentrate, loss of taste, and chills. The cortisone does relieve my hip pain, though, so as long as these side-effects are temporary and don't worsen, I'll continue with this treatment.


The term arthritis refers to stiffness in the joints. See Answer
Comment from: jm, 45-54 Female (Patient) Published: September 25

I have acute adhesive capsulitis (frozen shoulder). I received a cortisone injection into my shoulder yesterday (as well as hydrodilatation). I experienced facial flushing today, and am very tired. I also don't feel like eating. However, I have been in so much extreme pain for months, 24/7. I am so grateful and looking forward to the pain subsiding. I can already feel a difference. It is worth it if it removes the extreme pain.

Comment from: jaykay, 25-34 Male (Patient) Published: September 14

I had two cortisone injections on both my elbows (because I had ulnar nerve damage) and it really hurt, but the following day, I woke up with high grade fever. The fever would come on and off but it would be accompanied by chills along with low body temperature (along with night sweats). It has been 4 days since I have been having these symptoms and I rushed to the emergency room just to confirm I am not going into some kind of sepsis shock. Everything is normal but never again am I taking this shot.

Comment from: mike, 25-34 Male (Patient) Published: September 09

Forty-five minutes after the cortisone shot I developed uncontrolled shaking and sweating all night. The next night, I had fever of 101 with sweats, and bad diarrhea from day 2 to 6, mostly every hour. The steroid caused terrible rash and terrible headache off and on. The emergency room nurse says it is a virus but doubtful after reading other people’s reactions. I would rather have the flu than deal with this again.

Comment from: Linda, 55-64 Female (Patient) Published: August 06

I tore the meniscus on both sides of my knee. After four weeks, I decided to try cortisone injection. I felt fine for the first couple of hours and then bam, a massive headache. I have scheduled for a colonoscopy so I can't take pain relievers. So glad to see that I'm not the only one who suffered this headache. None of the websites list this as a side effect.

Comment from: Janeeloo, 65-74 Female (Patient) Published: July 09

I had cortisone shots in both my knees yesterday (and have had shots every 6 months for several years). Each time I have short-lived symptoms (usually over in 24 to 36 hours) of red flushed cheeks, sweats, trouble sleeping, and most typically, headaches. This time, my headache started on my way home from the doctor and is bad. The relief I get from the shots is worth the short-term side effects.

Comment from: Linda, 45-54 Female (Patient) Published: April 15

I had sacroiliac joint bilateral cortisone injections 4 days ago. The first night I had insomnia and was awake for over 24 hours. I then began to experience severe acid reflux, nausea, loss of appetite, loss of taste, chills, anxiety, mild headaches, stomach pain, and fatigue. Today is day 4 and the doctor told me to take Benadryl, and drink Gatorade. Don’t know if these side effects are worth it.

Comment from: Stephie, 55-64 Female (Patient) Published: April 13

I had a cortisone injection in my left hip joint 6 days ago. Since then, my stomach has felt as if I had a fire pit of hot burning coals inside it. I have experienced a frontal severe headache, on and off, not every day. My son tells me I haven't been very pleasant to be around, and we have always enjoyed being around each other. So I am wondering if these are somewhat normal side effects.

Comment from: Gayle, 65-74 Female (Patient) Published: April 03

I had a prednisone injection in the front of my swollen knee, due to a large Baker's cyst that appeared out of nowhere. I began feeling lethargic hours after the cortisone injection. The next day, I ran a fever for the entire day (100.5) and felt like I had the flu, except there were no gastric issues or any other flu symptoms. The fever broke around 2 AM, I woke up and felt normal. I don't want to go through that again. Yes, I'm sure the injection caused my symptoms.

Comment from: Shell, 35-44 Female (Patient) Published: March 05

I had a cortisone injection in my heel. I went to work that night. In the morning I had severe vertigo, fatigue and nausea. Wonder if that could be from the needle. I only had vertigo once before, about a year ago.

Comment from: Txpt, 35-44 Female (Patient) Published: February 27

I always have a cortisone flare but today takes the cake. The orthopedist injected my ankle this morning. By the time I drove from his office to mine (15 minutes) I was severely swollen and in excruciating pain. My calf has been extremely cold to the touch all day and this evening I have developed a massive headache; along with just a general malaise and feeling feverish. This was the last injection I'll ever get. In the past I've only gotten about 2 weeks pain relief anyway. I just don't think they work for me.

Comment from: rflight, 45-54 Female (Patient) Published: February 25

I had a cortisone shot in my hip 6 days ago. The day following the injection, I got a severe headache and nausea. I also felt shaky and seemed to get low blood sugar easily. I've had these symptoms for five days. Not sure I want to have another injection.

Comment from: Ethel, 75 or over Female (Patient) Published: January 31

After cortisone shots in both knees, I had severe headache for 48 hours. I felt like my head was going to burst. Now my knees are so bad but I cannot take cortisone again. I cannot take that headache again. I don’t know what to do for thi!

Comment from: Janice, 55-64 Female (Patient) Published: January 24

I had two cortisone injections to my finger joints in November 2019. I reacted badly this time despite having had them before. I suffered from facial flushing for 48 hours and a headache plus insomnia. I also had swelling, and hot, itching skin around an area of an old elbow injury. However, during the following month I experienced nightly sweats and issues with blood sugars (I am not diabetic). The site of one of the injections also broke out in a bad sore.

Comment from: NannyX2, 55-64 Female (Patient) Published: January 20

I had a cortisone injection in my left hip at 11:00 am today and by the afternoon around 4:00 pm my head started hurting. It’s now 10:00 pm and it feels like my head is going to explode! Also, I am extremely thirsty and can’t get enough to drink. I certainly hope this will subside soon.

Comment from: BlueAngel73, 45-54 Female (Patient) Published: December 11

I had a cortisone shot in my lower back and that evening I had to urinate every half hour, all night long. I couldn’t hold it at all, my bladder felt so full it hurt. The next day I was fine. This is the third one I have gotten and had these symptoms every time. I also had one in my neck and had the same reaction. I don’t see this listed as a side effect or anything anywhere. I guess it makes sense if the pressure and swelling goes does the fluid has to release somewhere.

Comment from: jfed, 65-74 Female (Patient) Published: November 25

I had a cortisone injection in my spine two months ago. It hurt like crazy during the procedure, but since then, A.O.K. Pain is gone. I had cortisone injection in my knee and was not too bad the first day. My knee hurts a little today, bit I need to remember to stay off of it and use ice. I do, however, have a flushed face (about 24 hours after the procedure), a headache (almost immediately), have been jittery for the past few hours, and had trouble sleeping last night. I hope the side effects go away soon.

Comment from: Caryn, 45-54 Female (Patient) Published: November 13

I had a cortisone injection in my left sacroiliac joint for sacroiliitis 5 days ago. The injection itself went ok except it hurt as she pushed the steroid into the joint. That night I had pain and difficulty sleeping. By the 3rd day I experienced depression and anger, hot face and extreme fatigue. The moods subsided but I'm still exhausted, and getting painful muscle spasms through my left buttock and where the injection point is, it still hurts. I've read it can take up to 2 weeks, hoping it improves!

Comment from: charlie, 55-64 Female (Patient) Published: November 12

I had a cortisone injection on my right hand for a trigger finger. It was numb for seven hours but once the numbness wore off my pain got worse.

Comment from: Smjh, 45-54 Female (Patient) Published: November 05

Cortisone injection definitely helps the pain but it kills me emotionally so much so it is the last resort treatment. My entire personality changes. I end up crying one minute and climbing the walls the next. I am irritable, restless, sad, agitated, can’t think normally, get my period within 24 hours of injection and it is nonstop for a month. I get a massive headache and my vision gets really blurred. I literally cannot manage the side effects, they make me so impaired. It is torture, absolute agony.

Comment from: michelle, 65-74 Female (Patient) Published: October 31

I went for my colonoscopy. It was awful, the pain of stomach cramps when she was turning the camera round, though it had gas and air didn’t do much good. And drinking the MoviPrep for 2 days beforehand was awful. It tasted like lemon salt water; never want to have it done again.

Comment from: Leah, 65-74 Female (Patient) Published: October 24

I received my first cortisone injection in my knee three days ago. It has helped the pain a lot, but I have had a mild headache, jumpiness, insomnia and horrible taste in my mouth. I honestly don't know if it is worth it to have these side effects.

Comment from: Ro1106, 65-74 Female (Patient) Published: October 15

I just wanted people to know these cortisone shots are not all bad. No side effects for me. Almost immediate relief. I had injections in my ankles. Foot pain kept me awake and I now can sleep through the night. Energy and no pain, felt like I had my life back.

Comment from: waldo, 45-54 Male (Patient) Published: October 08

I have very bad gout and it’s been getting worse over the years; even with around 600 mg of allopurinol it keeps coming back. I went to a different doctor and he suggested I take a cortisone shot and the side effects would only be a few days of uneasy sleep. How wrong he was! It took 24 hours for the gout attack to stop, which was ideal, however this was also accompanied by bad mouth thrush; zero taste buds, no appetite, bad mood swings, erectile dysfunction and hot face flushes. I am now into day 10. Never again!

Comment from: Fadi, 45-54 Male (Patient) Published: October 01

I had a cortisone shot yesterday after which I experienced sever fatigue. We thought I was having a stroke and I went to the hospital. Yesterday evening I had the most horrible nausea till 4 AM and started shaking uncontrollably. This morning, I was ok. This afternoon I had a lingering, persistent headache. Not worth it.

Comment from: Lynne, 55-64 Female (Patient) Published: September 19

I had cortisone injection to my left shoulder. I was advised by the doctor that there might be more pain in the shoulder the following day. Mine lasts several days with increased weakness. The worst thing is strong frontal headaches that last for days with little relief from pain medication. This is my third injection and it’s happened every time. I will advise my doctor in my next appointment. This side effect is not listed.

Comment from: Natalie, 65-74 Female (Patient) Published: September 18

It has been a week now since I had a cortisone shot in my right shoulder. That same night I had insomnia, a low-grade fever, flushing in my face and headaches that lasted 3 days after, along with a feeling that I can`t take a deep breath. I feel shaky and my blood pressure is lower than normal. Today it was 100/65. I am getting anxiety now because I can`t breathe deeply! And that shaky feeling is still with me as well. Wonder if this will subside. I`m getting more nervous each day.

Comment from: Drained , 55-64 Female (Patient) Published: September 17

After my cortisone injection I had severe diarrhea.

Comment from: Hockey777fan, 55-64 Female (Patient) Published: September 13

I get a severe headache that lasts 8 to 10 hours after the cortisone injection that no medication touches, including Vicodin. The shot pain lasts 30 minutes to an hour. This time I also got sweating and feeling warm.

Comment from: M. Bald, 25-34 Female (Patient) Published: September 13

I had my first cortisone shot in my knee. I immediately had a bad reaction. My blood pressure dropped, I had uncontrollable sweating, nausea, headache, and almost passed out. After 20 minutes I came around. Rest of the day I have been nauseous with a headache. Now I can’t sleep and I’m itching all over like crazy! My knee is throbbing and my whole leg muscles are so tight. Hoping this gets better the next few days.

Comment from: Dngraham74 , 55-64 Female (Patient) Published: August 13

I was stung by a wasp some people said it was a cicada killer. When it stung me I fell to the ground. That happened around to second week of June. I am still limping and my ankle swells and goes back down. I am really lost at what to do. I went to a doctor and to the hospital for x-rays and no one can tell me anything.

Comment from: Alice, 65-74 Female (Patient) Published: August 12

I have been getting cortisone injections in my knees for a few years. I have only had 2 bad reactions. The first one 5 years ago and one I received last week, both have had same reactions. At this moment, I just received one 7 days ago and I have overwhelming fatigue and malaise, nausea and dizziness, and pain is better but not gone. My orthopedist said wow, I've never heard that, most people feel better and energetic.

Comment from: Grace, 35-44 Female (Patient) Published: August 07

I had a Bartholin cyst for about 2 years before I had it drained. The first year it came and went, sometimes would stay for a week then go away for a few days. The second year it just stayed, it never fully went away, it got to be about the size of a golf ball. I went to see the gynecologist at the hospital because nobody could tell me what it was. She drained it for me that day, now I'm 6 days into my stitches, and it hurts terribly but it was totally worth it. I'm hoping it doesn’t come again.

Comment from: StaciMc, 45-54 Female (Patient) Published: August 06

Cortisone injection to my right knee relieved arthritic pain within 24 hours. I experienced face and chest flushing and I felt very warm and sweaty starting the day after the shot and continuing periodically for 3 days. I didn’t sleep well the first night after the injection. Although my sleep quality improved the next night, today is the 4th day post injection and I continue feel somewhat agitated and very tired.

Comment from: kelley, 55-64 Female (Patient) Published: August 06

I had my second cortisone injection in my left knee yesterday, and here I am at 6:25 am wide awake! My stomach is a bit sour, yet I have felt hungry ever since the injection. My last injection was in February and it did not work, in fact I experienced extreme muscle weakness and pain following the injection. This time with a different doctor who injected it through the pain site, my knee is feeling better. I hope I can get some sleep though! I hope the knee relief continues.

Comment from: jayne, 55-64 Female (Patient) Published: July 30

I wonder how long the cortisone injection side effects of headache and flushing in the face last. I feel awful and I want it to just go away. No pain reliever is helping to clear my head.

Comment from: Anynamewilldo, 45-54 Female (Patient) Published: July 29

I had a cortisone shot in my shoulder joint, and within 20 minutes, part of my tongue and the roof of my mouth on that side were numb. The 2nd day I started getting really red faced and sweating profusely, also my teeth feel weird, almost like they are brittle, and they ache. Also, I have an occasional feeling that someone is tapping me on that shoulder, and the feeling of something crawling under my skin in that shoulder. Am also having a bitter, weird taste in my mouth despite brushing and using mouthwash.

Comment from: Lily, 55-64 Female (Patient) Published: July 23

I had a cortisone injection in my shoulder six days ago for tendonitis and since then have been having headaches and dizziness. Today has been the worst. Wish I hadn't bothered.

Comment from: Smgarrett09 , 35-44 Female (Patient) Published: July 22

I have had a headache for 4 days after a cortisone shot in my lumbar spine. My back feels better but this headache was not worth it. I hope it goes away soon.

Comment from: Sunny, 55-64 Female (Patient) Published: July 15

I had a steroid shot in knee in the afternoon, became dizzy (like motion sickness) by the evening. Pain and movement in knee have improved fantastically, but I am a bit worried about dizziness; the next morning it is still here along with headache.

Comment from: Wifeofchefj9, 55-64 Female (Patient) Published: July 02

I suffered a fibula break. And I cracked the heel bone. I was in a surgical cast for 2 weeks. Then they put me in a regular cast for 6 weeks. I just got that cast off a week ago. My doctor showed me that both bones have healed. But my problem is that I can't put any weight on my foot. Because it hurts too badly around my ankle area. And I mean a lot of pain. Im in a boot. My anniversary is in September, and we are in June. I am just afraid that I won’t be able to walk on it by then.

Comment from: Flat feet, 55-64 Female (Patient) Published: July 02

The pain in the arch of my feet started about the 4th week of cardiac rehabilitation. I have tried several medications but what gives me more relief is Vicks VapoRub on my arches and putting a sock on before bed time to prevent messing up the sheet.

Comment from: Brown1108, 75 or over Female (Patient) Published: July 02

I first started with lower back pain which then traveled to left side pelvic area and leg to the point I couldn’t walk. Stabbing pain that wouldn’t let up. Ibuprofen and Tylenol would not work. The pain was so bad that I didn’t even feel this when I was in labor. I had to crawl or walk bent over to use the restroom. I got an ultrasound done first which said all was normal then I did a CT scan which showed diverticulosis. I am on 2 antibiotics but am on my 3rd day with only slight improvement.

Comment from: Carole54, 65-74 Female (Patient) Published: July 01

I just had a cortisone shot in my left knee yesterday and the pain relief for the knee is amazing. It is the first time in about a year that I have been able to walk and stand without pain. However, I am experiencing facial flushing and a horrible persistent headache. When I researched side effects, headache isn't listed. It has been reassuring to read that others are experiencing this side effect.

Comment from: Jb, 45-54 Female (Patient) Published: June 26

After my cortisone injection I had migraine with tightness or pressure in my jaw and sharp red hot pokers in eyes. I also had muscle weakness with dizziness upon rising (enough to go down and hit the deck), nausea and general malaise.

Comment from: Debbie , 65-74 Female (Patient) Published: June 07

I got a cortisone shot in my left knee last week. A few days later my stomach started getting upset. It has been that way for the past 5 days. Constant gurgling noises in my intestines, gas, and frequent bathroom visits. I have also been very tired. I really think it is the shot because this happened to me several months ago after a shot. Lasts about 2 weeks. Hopefully I can hold out and not get another one before my knee replacement in September. Hope you all feel better soon.

Comment from: Jtennis20 , 65-74 Male (Patient) Published: June 04

I had a cortisone shot in my back and 7 hours later I became dizzy and had dry heaves. I lay on the bathroom floor 4 hours before I could get up and go to bed because of being dizzy.

Comment from: Marg, 45-54 Female (Patient) Published: June 03

I usually suffer from headaches for the first three days after a cortisone injection, feel very tired, can’t concentrate and just want to stay in bed.

Comment from: Ms K, 45-54 Female (Patient) Published: May 31

I have had several cortisone shots in my knees. I have always had really bad migraines at least the 1st day, sometimes 2 or 3 days. Just got cortisone shots in my shoulders and for 3 days migraine was bad. It is the 3rd day today, and all day my taste and smell are like metal or the medicine. Nothing is helping, not mints, nothing. I will continue to get injections in my knees because I have to. But no more in my shoulders, too much. I hate being this sick.

Comment from: Glenda , 55-64 Female (Patient) Published: May 29

I had a cortisone shot in my hip for allergies and the next day I started getting real hot in my face and my cheeks were very red. And 1 1/2 weeks after my shot I started getting real weak and getting the weak shakes, and I stayed weak and had no energy all the time. I did not have that till I got that shot, never done before when I had them, except for the flushed face. I wonder how long the effects of the shot will last, I'm never getting anymore.

Comment from: Shirlnga, 75 or over Female (Patient) Published: May 21

On March 30, 2019, I was given a steroid injection in the hip for costochondritis. I became ill on the way home from the Urgent Care facility and I have not been well since then. I’m constantly fatigued, absolutely no energy, my joints ache and I am short of breath on the slightest exertion. I’m normally a very active person and had mowed my entire yard the day before this happened and felt great. There is absolutely no doubt that what I’m experiencing is from the injection.

Comment from: Peter, 55-64 Male (Patient) Published: May 20

I had a Kenalog cortisone injection in my palm and finger. Six weeks later I am still dealing with awful side-effects. Horrible sleeplessness, sore, tight and cramping muscles, acidic grumpy stomach, constant thirst, and metallic taste that lasted couple weeks, general fatigue and malaise. On and on. Nothing like this has ever happened to me before. I never had these symptoms till the shot, which was strictly a prophylactic measure following procedure on hand. Long-acting suspension they call it. I wonder how I can detox.

Comment from: Gary, 55-64 Male (Patient) Published: May 14

I had a cortisone injection in my left hip on Friday. I could feel it run down my leg on the inside, now my foot is in so much pain!

Comment from: Concerned wife, 35-44 Female (Caregiver) Published: May 07

My husband just got the facet lumbar cortisone injections on Friday and is having horrible chills and hot flashes. I wonder how long the symptoms last.

Comment from: Ian, 75 or over Male (Patient) Published: April 30

After about 12 months of increasing pain and stiffness mainly in the glutes with less in the hamstrings and calf muscles, the doctor did arthritis profile blood tests which showed ESR 40 (reference range 0-15), C-reactive protein 65 (reference range 5), indicating polymyalgia rheumatica. He gave me a cortisone shot in the behind and within 4 hours all pain and stiffness had gone. I now take 2 prednisone tablets per day, and have been back for another shot at 3 monthly intervals. Due for another shot now being my 4th.

Comment from: Jen C., 45-54 Female (Patient) Published: April 18

I had a cortisone injection to a painful bursa (horrendous pain for 27 months) in my right hip. The injection was well tolerated the day of and after the injection. The injection was Monday and today is Wednesday. This morning I woke up to bright red cheeks, horrendous pain in my right hip spreading to my right buttock, feeling flushed and hot and incredibly irritable. I’ve had many injections to my shoulder and hip and have had a flare up of pain on occasion but this is over the top.

Comment from: Alysia, 55-64 Female (Patient) Published: April 17

I’ve got severe pain in both my knees. I’ve had cortisone shots in both my knees and had the red face and high blood pressure. I got one in my left knee yesterday and have had an awful ongoing pain, nothing will touch the pain in my head migraine. But without this shot I cannot walk so I have to deal with the pain in my brain for a few days to have months of relief in my knees and walking ability. I wish I didn’t have this headache but it is my only relief! Thank you.

Comment from: Pete, 75 or over Male (Patient) Published: March 28

I had a cortisone shot in my knee after drainage. It gave relief but I had esophageal spasms (suffer with achalasia) for 5 hours while in bed, so little sleep. Hoping tonight is better. Good luck to you all.

Comment from: Penny, 45-54 Female (Patient) Published: March 26

I had a cortisone injection in my hip over 2 weeks ago. I've had terrible side effects. I have had constant motion sickness type of feeling, sweating and my taste buds are hardly working. I've had to take 2 weeks off work because of the dizziness which I still have! Side effects have been completely debilitating. Never again will I have a cortisone injection. It has been a nightmare which is still ongoing.

Comment from: Trisha, 45-54 Female (Patient) Published: March 25

I have had 5 cortisone injection shots in my knees in a year. I couldn't pinpoint where the hot flashes was coming from. I was told I'm in pre-menopause. This last injection in February 2019 was the worst. I now have night flashes where the back of my neck is soaked and hot as can be. I am sweating everywhere and in the day time on and off all day. I hope this night mare ends soon.

Comment from: Kayleigh , 25-34 Female (Patient) Published: February 26

I had a cortisone injection into my right knee yesterday afternoon. I felt fine until I went to bed, and then had terrible sweating but I was absolutely freezing. I feel so tired and have a headache. I also got a temperature of 37.8 this morning. My knee is still very painful.

Comment from: Ann, 55-64 Female (Patient) Published: February 25

I had a cortisone injection in my right knee after I got home! I developed a terrible headache and red and hot cheeks, even my teeth hurt. I don’t know what to do for it.

Comment from: Joyce, 75 or over Female (Patient) Published: February 08

I received my cortisone injection yesterday, and my blood sugar went to over 500 by 6 pm, and the shot was done around noon. It is still 382 at 7:30 the next morning and says it is still coming down. Be aware this may happen if you are diabetic. My average scan for the last 24 hours has been 423mg/dl. I am still a little tired this morning.

Comment from: Freesia , 65-74 Female (Patient) Published: February 07

I suffer from osteoarthritis. I experience pain in all joints. I got cortisone injections in both shoulders from my general physician, which were very painful. He administered them while I sat on a chair. He stood behind me and injected both shoulders from behind. While getting dressed I felt faint. I was helped into another room and a nurse helped me onto a bed where I had to stay till I could walk. I lost the power to speak properly and felt drunk. I am a teetotaler so it wasn’t because I had been drinking.

Comment from: Aggie91, 45-54 Female (Patient) Published: February 05

I had a cortisone injection for my shoulder. It made me super hyper, with panic attack symptoms like difficulty breathing, etc. I am pretty sure it was made worse with my ADHD medicine. I’d recommend not taking your ADHD medicines the same day. I’m pretty tolerant usually, and the last 18 hours were awful.

Comment from: Steve M., 65-74 Male (Patient) Published: January 30

I had a cortisone/prednisone combo shot in my shoulder yesterday about 10:30 am for tendonitis. About 8:30 last night I got very sick at my stomach and got up to go to the bathroom where I was having pain in my upper spinal column, was very dizzy and white as a ghost. I lay down for about an hour and felt better but as soon as I got up I was experiencing the same dizziness and still today I am experiencing stomach pain and trouble breathing while walking around.

Comment from: Tricia, 75 or over Female (Patient) Published: January 30

I had cortisone injections yesterday for a right shoulder massive, non-repairable rotator cuff tear and left knee bone on bone. Horrendous headache won’t go away since then!

Comment from: Bobbie, 35-44 Female (Patient) Published: January 24

I had 12 cortisone injections on my right side and my neck and shoulder, and four on the left today. Felt great pretty quick but then I started getting fevers and chills. I can't sleep at all and feel extremely nauseous. I've had this done before and I don't remember all of this although that that was several years ago.

Comment from: Corinna , 45-54 Female (Patient) Published: January 18

October 2018 I had 6 cortisone shots in my spine, 2 weekly for 3 weeks. I have been shaky and get intense nausea every day ever since. I can't live like this.

Comment from: Di, 65-74 Female (Patient) Published: January 14

I got a cortisone injection in my hip. The spot where the shot was given is very sore. I have hot then cold feeling. Face is flushed and I feel very sleepy. Also have a slight blurred vision.

Comment from: Alle88, 45-54 Female (Patient) Published: January 10

I just got a cortisone injection in my knee today and I have the worst headache. Came on about five hours after the shot. I wonder how long it will last.

Comment from: Ohioskinner, 55-64 Female (Patient) Published: January 04

I am having the same types of side effects from cortisone injection I’m reading about here. Nervousness, anger, depression, panic attacks, swimmy head, confusion... My doctor assured me this doesn’t happen. I know my body and this is not how I normally feel. The only thing I have done differently lately is get a cortisone injection into my left hip joint space and, voila, all this started. Frankly, it’s very scary.

Comment from: Buckroe, 55-64 Male (Patient) Published: December 26

I had a cortisone shot to my left knee. My knee feels great, but not much sleep and have terrible gas and sour stomach. I wonder how long these symptoms last.

Comment from: Smckin0005, 45-54 Female (Patient) Published: December 20

I had a cortisone injection in my right knee yesterday. I had my first injection a year and a half ago with no problems. This time I have the worst pounding headache, extremely flushed cheeks, kind of foggy brain, bothered to the point of angry for no really good reason, blurry vision, shakiness, loss of some of my voice, what feels like high blood pressure and a difficult time sleeping. This is crazy, I don’t think I’ll do this again. However, the pain in my knee is almost gone.

Comment from: [email protected], 55-64 Female (Patient) Published: December 17

I had a cortisone injection this morning. I experienced fatigue soon after and a headache in the evening. My knee feels great though, better than last time.

Comment from: harley, 75 or over Female (Patient) Published: December 17

I had steroid injection for a torn meniscus, now I notice my blood pressure has increased especially the diastolic. I wonder if the cortisone injection could be the cause and hope the effects are not lasting.

Comment from: Sherty, 55-64 Female (Patient) Published: December 11

I had a cortisone shot put in my left thigh in the emergency room for right side sciatic nerve pain. Next morning I had severe gas sulfur burps. I have had shots before directly into the nerve at outpatient surgery, and never had burps or gas.

Comment from: kpohio, 55-64 Female (Patient) Published: December 05

Thanks to all who shared. I had a cortisone shot in my knee yesterday. I felt great until the evening. I did experience a hot flash and sweating, especially facial and thought perhaps a reaction to the shot. This morning I feel extremely fatigued and frustrated with that because I was just starting to feel more energetic from recent dosage reduction of other medicines. My knee is pain free, and it is a relief to move without the pain. Somewhat reassuring to know potential cause of these symptoms.

Comment from: CB, 65-74 Female (Patient) Published: December 04

I experienced indigestion, insomnia and swelling of the belly after my cortisone injection. I feel that these are minor discomforts in relation to the immediate relief that I received after the injection from the pain in my knee. It had been aching for months.

Comment from: Bendigo, 55-64 Female (Patient) Published: November 26

I had a cortisone injection in my shoulder two days ago. About 10 hours after the injection a severe headache in the occipital region, facial flushing and tingling began - and continue. Over the counter pain relievers dull the headache but it returns in full force as soon as they wear off.